How can we prevent course creators from making changes to other instructors’ content within the same course in Open edX?
You can’t.
You can create a separate course for each instructor.
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Hi @abdulahadtp!
I’m afraid this is not possible. Once a user has been granted a course creator permission under a specific organization, they will have the option to create and edit all the courses in that specific organization. Therefore, I believe it is only possible to restrict the course creator access, per organization and not per course.
I would also like to share the following documentation, which explains the roles and permissions in Open edX: Roles and Permissions Open edX — Public documentation
I hope you find this information helpful! 
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